2026-10-19T00:02:04Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/102552026-10-18T20:25:30Zopenairedrivercom_ebyu_10000col_ebyu_10001

Meta-analysis of Maternal and Fetal Outcomes of Crimean-Congo Hemorrhagic Fever during PregnancyDonk, BaharGüllü, DenizCırık, Ahmet MirhanAlay, HandanKarakeçili, FarukÖzden, KemalettinCan, Fatma KesmezBarkay, OrçunPshenichnaya, NataliaErgönül, ÖnderAdultAntiviral AgentsFemaleHemorrhagic Fever Virus, Crimean-CongoHemorrhagic Fever, CrimeanHumansMaternal MortalityPregnancyPregnancy Complications, InfectiousPregnancy OutcomeRibavirinantivirus agentCrimean Congo hemorrhagic feverCrimean-Congo hemorrhagic fever virusdrug therapyepidemiologyhumaninfectious pregnancy complicationmeta analysismortalityvirologyCrimean-Congo hemorrhagic fever (CCHF) during pregnancy is associated with severe maternal and fetal complications, but evidence remains limited to heterogeneous case reports. We synthesized patient-level data from published and unpublished cases identified through systematic database searches and direct collaboration with centers in CCHF-endemic areas. We harmonized patient-level clinical, laboratory, obstetric, treatment, and outcome data for 55 pregnancies. The maternal mortality rate was 28.8% (15/52), and fetal loss occurred in 57.4% (31/54) of cases. Maternal mortality rates increased with advancing gestation, reaching 31.3% in the third trimester, but fetal loss was highest (85.7%) in the first trimester. Ribavirin treatment during the third trimester was associated with lower observed maternal mortality rates (odds ratio 0.33, 95% CI 0.13–0.84; p = 0.031). Our findings highlight gestational age–specific risks of CCHF and support the need for standardized management protocols and strengthened CCHF surveillance during pregnancy in endemic regions. © 2026, Centers for Disease Control and Prevention (CDC). All rights reserved.Centers for Disease Control and Prevention (CDC)2026Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/10255https://doi.org/10.3201/eid3210.2603831080-6040enEmerging Infectious Diseasesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/10255