2026-10-19T01:56:55Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/104312026-10-18T21:13:05Zopenairedrivercom_ebyu_10000col_ebyu_10001

Investigation of the Protective Effect of Centella asiatica Against Doxorubicin-Induced Testicular Damage in RatsBedir, FevziSuleyman, ZeynepKocaturk, HuseyinAltay, Mehmet SefaKeskin Cimen, FerdaAltuner, DurduBabayeva, MansuraSuleyman, HalisCentella asiaticadoxorubicinratreproductiontesticularAnimalsAntibiotics, AntineoplasticAntioxidantsCentellaCytokinesMaleMalondialdehydeNitric OxideOxidative StressPlant ExtractsProtective AgentsRatsSuperoxide DismutaseTestisTriterpenesadrimisinCentella asiatica extractcytokinehormoneinterleukin 1betainterleukin 6malonaldehydetumor necrosis factorantineoplastic antibioticantioxidantDoxorubicin (DOX) is an antineoplastic agent commonly used in cancer therapy that is known for its testicular toxicity. DOX-induced testicular injury involves inflammation, reactive oxygen species, and oxidative stress. Centella asiatica exhibits anti-inflammatory and antioxidant properties. The present experimental study aimed to determine the potential protective efficacy of Centella asiatica in a rat model of doxorubicin-induced testicular toxicity. Rats were randomly assigned to four groups: healthy control (HC), CA, DOX, and CA + DOX (CADX). An oral dose of 200 mg/kg Centella asiatica was administered to the CA and CADX groups. The HC and DOX groups received saline. One hour later, DOX (7.5 mg/kg) was intraperitoneally injected into the DOX and CADX groups on days 1, 4, and 7. Centella asiatica markedly attenuated the DOX-induced increase in malondialdehyde, nitric oxide, and pro-inflammatory cytokine levels, while preventing the decrease in superoxide dismutase activity in testicular tissue (p < 0.001). Centella asiatica reduced the severity of DOX-induced morphological damage in testicular tissue (p < 0.05). Moreover, it partially restored reproductive hormone function. In conclusion, Centella asiatica demonstrates significant potential in mitigating DOX-induced oxidative damage, attenuating testicular injury and preserving the functional integrity of the male reproductive system. © 2026 by the authors.Multidisciplinary Digital Publishing Institute (MDPI)2026Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/10431https://doi.org/10.3390/ijms271778831661-6596enInternational Journal of Molecular Sciencesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/10431