2026-10-18T23:53:59Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/109352026-10-18T21:13:10Zopenairedrivercom_ebyu_10000col_ebyu_10001Columnar cell variant of papillary thyroid carcinoma in an adolescent: a comprehensive histopathological, immunohistochemical, and molecular analysisIssin, GizemDemir, FatihCagatay, Diren VuslatYilmaz, Ismailcolumnar cell variantpediatric endocrine neoplasmspediatric thyroid carcinomarare thyroid tumorthyroid carcinoma prognosisAdolescentCarcinoma, PapillaryFemaleHumansImmunohistochemistryThyroid Cancer, PapillaryThyroid Neoplasmscase reportgeneticshumanpapillary carcinomapathologyproceduresthyroid papillary carcinomathyroid tumorThe columnar cell variant (CCV) of papillary thyroid carcinoma (PTC) is a rare histological subtype with distinct morphological and immuno-histochemical (IHC) features, which can present diagnostic challenges. We report a case of a 13-year-old girl diagnosed with CCV of PTC (CCV–PTC) following a total thyroidectomy for a solitary thyroid nodule. Histopathological (HP) examination revealed aggressive features, including vascular invasion and extrathyroidal extension. However, no metastases or recurrences were observed during six years of follow-up. This case report provides a comprehensive analysis of a rare CCV–PTC in an adolescent, focusing on its HP, IHC, and molecular characteristics. It also discusses diagnostic pitfalls and differential diagnoses that should be considered. © 2025, Publishing House of the Romanian Academy. All rights reserved.Publishing House of the Romanian Academy2025Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/10935https://doi.org/10.47162/rjme.66.3.171220-0522enRomanian Journal of Morphology and Embryologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/10935