2026-10-18T23:54:21Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/110782026-10-18T21:13:16Zopenairedrivercom_ebyu_10000col_ebyu_10001Phytochemical analysis and biological evaluation of essential oils and extracts from Heracleum pastinacifolium subsp. incanum (Boiss. & A.Huet) P.H.Davis, an endemic plant from TurkeyYuca, HafizeSefalı, AbdurrahmanAydın, BilgeKaradayı, MehmetGülşahin, YusufYazıcı, AyşenurKarakaya, SongülDemirci, BetülÇoban, FurkanÖzdemir, ErkanDemir, Abdussamed YasinGüvenalp, ZühalAlzheimer’sdiabetesgenotoxicHeracleum pastinacifolium subsp. incanumhesperidinmyristicineAntioxidantsCholinesterase InhibitorsFlowersFruitGas Chromatography-Mass SpectrometryGlycoside Hydrolase InhibitorsHeracleumHypoglycemic AgentsOils, VolatilePhenolsPhytochemicalsPlant Components, AerialPlant ExtractsPlant RootsTurkeyalglucosidase alfaalpha glucosidaseantidiabetic agentapiolebeta pinenecholinesterase inhibitoressential oilferulic acidflower extractEssential oil content of and phenolic compounds flower-fruit, root, and aerial parts of Heracleum pastinacifolium subsp. incanum were analysed by GC/MS and LC/MS methods, respectively. Antidiabetic, anticholinesterase, and antioxidant activities of flower-fruit, root, aerial parts methanol extracts were evaluated. Apiole (35.0%), myristicine (72.2%), and myristicine (15.1%) were found as major compounds of fruit-flower mixture, root, aerial part essential oils, respectively. Hesperidin was found the highest amount in aerial part and flower-fruit extracts with 8904.2621 ng/mL and 11558.3634 ng/mL values, respectively. Fruit-flower extract showed the highest activity against α-glucosidase (24%). Root extract demonstrating the highest activity (18%) against AChE enzyme. Flowers-fruits mixture methanol extract had a higher % inhibition value on ABTS·+ and DPPH•. Flowers-fruits mixture methanol extract was rich in total phenol, total tannin, and protein content. All the extracts were determined as genetoxically safe according to the results of Ames/Salmonella, Escherichia coli WP2 and Allium cepa assays. © 2024 Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd.2025Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/11078https://doi.org/10.1080/14786419.2024.23726611478-6419enNatural Product Researchinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/11078