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Protective effect of adenosine triphosphate against cisplatin-induced necrotic and degenerative oral mucositis in ratsSalcan, IsmailDilber, MuhammedSuleyman, ZeynepYucel, NurinisaSalcan, SaraKesan, SefaYazici, Gulce NazCelik, FatihKoseturk, MerveAlp, Nurdan AlcanSuleyman, HalisAdenosine triphosphateCisplatinOxidative injuryRatTongueAnimalsAntineoplastic AgentsCytokinesMaleMouth MucosaNecrosisOxidative StressRandom AllocationRats, WistarReproducibility of ResultsStomatitisTime FactorsTreatment Outcomeantineoplastic agentcytokineanimaldrug effectdrug therapyevaluation studypathologyprevention and controlrandomizationreproducibilitytime factorWistar ratInflammation, oxidative damage, and adenosine triphosphate (ATP) depletion play a role in the7 pathogenesis of cisplatin (CIS)-induced oral mucositis. Objective: The purpose of this research is to examine8 the impact of ATP against potential oral mucositis development in cisplatin-treated rats. Methodology All rats9 were randomly assigned to four groups, namely healthy control group (HG), ATP group (ATPG), Cisplatin10 group (CISG), and ATP + Cisplatin group (ATCS). Firstly, ATP 4 mg/kg was administered via intraperitoneal11 injection (IP) to both ATPG and ATCS groups. The same volume of normal saline was injected into HG and12 CISG groups. After 1 h, cisplatin 5 mg/kg was administered via IP to CISG and ATCS groups. The drugs13 were taken 1x1 for 7 d. Later, tongue tissues were collected from all groups. Biochemical, macroscopic,14 and histopathological examinations were performed on all tissues. Results: ATP inhibited cisplatin-induced15 oxidative damage and pro-inflammatory cytokines levels in tongue tissue. In the CIS group, a significant16 number of distinct sulcus formations were found in the apex and corpus, as well as a few ulcer foci in the17 corpus, significant papilla loss, and bleeding. Meanwhile, in the ATP group, a similar appearance to healthy18 tissue was observed. Histopathologically, it was determined that in cisplatin-aggravated tongue tissue19 damage, filiform papillae decreased when ATP was administered, and the arrangement and structures of20 the epithelium, blood capillaries, muscle groups, and adipose cell groups were normal. Conclusions: Oral21 mucositis caused by cisplatin is alleviated by ATP. These findings may be useful for developing new therapeutic22 approaches to prevent or treat mucositis, a side effect so severe that can lead to treatment discontinuation.23 24. © 2025, Faculdade de Odontologia de Bauru da Universidade de Sao Paulo. All rights reserved.Faculdade de Odontologia de Bauru da Universidade de Sao Paulo2025Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/11141https://doi.org/10.1590/1678-7757-2025-00071678-7757enJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/11141