2026-10-18T23:15:48Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/112892026-10-18T20:26:21Zopenairedrivercom_ebyu_10000col_ebyu_10001

Therapeutic Effects of tDCS on Calcium and Glutamate Excitotoxicity in a Cerebral Ischemia–Reperfusion Rat ModelAkcay, GuvenDemirdogen, FilizKotan, DilcanGul, TubaYilmaz, AliErgul, Yusuf MuslumCelik, CaglaExcitotoxicityGlutamateIschemia–reperfusiontDCSAnimalsBrain IschemiaCalciumDisease Models, AnimalGlutamic AcidHippocampusMaleRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateReperfusion InjuryTranscranial Direct Current Stimulationn methyl dextro aspartic acid receptoranimaldisease modelmetabolismproceduresratSprague Dawley rattherapyAIM: To investigate the therapeutic effects of transcranial direct current stimulation (tDCS) on calcium and glutamate excitotoxicity caused by ischemia–reperfusion (IR). MATERIAL and METHODS: The IR model was generated by transient middle cerebral artery occlusion. tDCS treatment was applied at 1 mA for 30 min daily at the 2nd, 24th, and 48th h of IR. The motor and cognitive functions and the concentrations of Ca2+, glutamate, and N-methyl-D-aspartate receptor (NMDAR) in the hippocampus tissues were evaluated. RESULTS: Results showed a reduction in motor and cognitive functions in the IR group compared with that in the sham group, whereas these functions increased in the IR+tDCS group compared with those in the IR group. Ca2+, glutamate, and NMDAR concentrations were higher in the IR group than in the sham group but lower in the IR+tDCS group than in the IR group. CONCLUSION: These results suggest that tDCS treatment improves motor and cognitive dysfunctions after IR and exerts therapeutic effects on learning and memory through the regulation of Ca2+ and glutamate excitotoxicity. © This work is licensed by “Creative Commons Attribution-NonCommercial-4.0 International (CC)”.Turkish Neurosurgical Society2025Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/11289https://doi.org/10.5137/1019-5149.jtn.46166-23.61019-5149enTurkish Neurosurgeryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/11289