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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/118662026-10-18T20:26:51Zopenairedrivercom_ebyu_10000col_ebyu_10001

Biological and in Silico Studies on the Benzimidazole-Based CompoundsBayar, IremTurkmenoglu, BurçinAkkoc, SenemBenzimidazoleCytotoxic ActivityMolecular DockingTwo 1,2-disubstituted benzimidazole-based compounds (2 and 3) were synthesized in this study. The antiproliferative activities of these compounds 1-(4-methylbenzyl)-2-p-tolyl-1H-benzo[d]imidazole (2), 1-(3-methoxybenzyl)-2-p-tolyl-1H-benzo[d]imidazole (3) together with cisplatin as a positive control drug were performed by the MTT method against the MDA-MB-231 breast cancer cell line. Compound 2 exhibited relatively higher cytotoxic activity. Molecular docking studies of compounds were performed against five breast cancer targets (PARP5A, PARP1, Bcl-2, JAK2, CDK4). By interacting with these targets, effective amino acid residues and binding parameter values in the binding site were determined. © The Tunisian Chemical Society and Springer Nature Switzerland AG 2024.Springer Science and Business Media Deutschland GmbH2024Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/11866https://doi.org/10.1007/s42250-024-00893-72522-5758enChemistry Africainfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/11866