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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/119012026-10-18T21:13:18Zopenairedrivercom_ebyu_10000col_ebyu_10001

Two new compounds from endemic Centaurea paphlagonica (Bornm.) Wagenitz and their cytotoxic activitiesTüfekçi, Ali RızaDemirtaş, İbrahimAkşit, HüseyinArslan, ŞevkiKocabıyık, KübraZeybek, SibelOzen, TevfikKöksal, Ekremantiproliferative activityAsteraceaeCentaurea paphlagonicaisolationMTTAntineoplastic AgentsCaco-2 CellsCentaureaChlorogenic AcidHEK293 CellsHumansMethyl EthersPlant Extracts3 o feruloylquinic acid3,4 dihydroxy benzoic acid5 o caffeoylshikimic acid8alpha o (2',3' dihydroxyisobutyryl)desacylcynaropicrinalkaloidcatecholCentaurea paphlagonica extractchlorogenic acid methyl estercirsiliolcynarinedesacylcynaropicrindiosmetin 6 c beta glucopyranosideflavonoidflavonoid glycosideglycosideherbaceous agentisoorientinCentaurea paphlagonica (Bornm.) Wagenitz is an endemic plant in Turkey. Pyrocatechol, vanillic acid, 3,4-dihydroxy benzoic acid, 5-O-caffeoylshikimic acid, tamarixetin, chlorogenic acid methyl ester, quercetin, 1,3-dicaffeoylquinic acid, tamarixetin-7-O-β-D-glucopyranoside, quercimetrin, daucosterin, paphlagonicanin B, tamarixetin-7-O-β-rutinoside, rutin, chlorogenic acid, isoorientin, orientin, 3-O-feruloylquinic acid, quercetagetin-3-methyl ether 6-O-β-glucopyranoside, diosmetin 6-C-β-glucopyranoside, quercetagetin 4′-methyl ether 7-O-β-glucopyranoside, paphlagonicanin A, nepetin, cirsiliol, desacylcynaropicrin, and 8α-O-(2′,3′-dihydroxyisobutyryl) desacylcynaropicrin were isolated from both flower and aerial parts of C. paphlagonica. These compounds were identified using 1D and 2D NMR methods and ESI-MS. The MTT assay assessed the antiproliferative activities of all isolated (known and new compounds) compounds on Caco-2, LNCaP, A549, HeLa, and HEK-293 cell lines. The 8α-O-(2′,3′-dihydroxyisobutyryl) desacylcynaropicrin demonstrated the highest activity against CaCo-2 and HeLa cancer cell lines. © 2023 John Wiley & Sons Ltd.John Wiley and Sons Inc2024Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/11901https://doi.org/10.1111/cbdd.144091747-0277enChemical Biology and Drug Designinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/11901