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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/119322026-10-18T21:13:21Zopenairedrivercom_ebyu_10000col_ebyu_10001

Protective Effect of Adenosine Triphosphate against 5-Fluorouracil-Induced Oxidative Ovarian Damage in vivoOzer, MehmetInce, SefaAltuner, DurduSuleyman, ZeynepCicek, BetulGulaboglu, MineMokhtare, BehzadGursul, CebrailSuleyman, Halis5adenosine triphosphatefluorouracilinflammationovarianratreproductiveAnimalsFemaleOvaryOxidative StressRatsanimalObjective: The aim of our study was to analyze the effect of ATP on possible ovarian damage of 5-FU in rats. Methods: The animals were divided to three groups; healthy group (HG), 5-FU alone group (FUG) and ATP+5-FU administered group (AFU). The ATP 4 mg/kg was injected intraperitoneally (IP) into the AFU group. The same volume of saline (0.9% NaCl) as the solvent was administered intraperitoneally to the HG and FUG groups. One hour after administering ATP and solvent, 5-FU 100 mg/kg was injected intraperitoneally to the animals in the AFU and FUG groups. ATP was administered to the animals once a day for 10 days. On the 1st, 3rd and 5th days of 5-FU, one dose (total of 3 doses) was administered. On day 10, the animals were euthanasia with high-dose anaesthesia and ovarian tissues were removed. The removed ovaries were analyzed biochemically andhistopathological. Result: ATP significantly suppressed both the increase in MDA and IL-6 levels, and the decrease in tGSH, SOD and CAT levels. Treatment with ATP significantly suppressed the severe vacuolization and primordial follicle degeneration induced by 5-FU in our study. Conclusion: ATP was possible to be useful for the treatment of 5-FU-induced ovarian damage. © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.Asian Pacific Organization for Cancer Prevention2023Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/11932https://doi.org/10.31557/apjcp.2023.24.3.10071513-7368enAsian Pacific Journal of Cancer Preventioninfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/11932