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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/119732026-10-18T21:13:19Zopenairedrivercom_ebyu_10000col_ebyu_10001

Enhanced efficacy of resveratrol-loaded silver nanoparticle in attenuating sepsis-induced acute liver injury: Modulation of inflammation, oxidative stress, and SIRT1 activationÜstündaǧ, HilalKalindemirtaş, Ferdane DanişmanDoǧanay, SongülDemir, ÖzlemKurt, NezahatHuyut, Mehmet TahirÖzgeriş, BetülKariper, İshak Afşinantioxidant propertiesliver injuryPolymicrobial sepsispro-inflammatory cytokinesresveratrolsilver nanoparticles (AgNPs)AnimalsChemical and Drug Induced Liver Injury, ChronicCytokinesInflammationMetal NanoparticlesNF-kappa BOxidative StressRatsSepsisSilverSirtuin 1Vascular Endothelial Growth Factor Aimmunoglobulin enhancer binding proteininterleukin 1betainterleukin 6silver nanoparticletumor necrosis factorvasculotropincytokinemetal nanoparticlevasculotropin Aanimal experimentanimal modelArticleSepsis-induced acute liver injury is a life-threatening condition involving inflammation, oxidative stress, and endothelial dysfunction. In the present study, the preventive effects of resveratrol (RV) alone and RV-loaded silver nanoparticles (AgNPs + RV) against sepsis-induced damage were investigated and compared in a rat model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Rats were divided into four groups: Sham, CLP, RV, and AgNPs + RV. Pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation, presepsin, procalcitonin (PCT), 8-hydroxy-2′-deoxyguanosine (8-OHDG), vascular endothelial growth factor (VEGF), and sirtuin-1 (SIRT1) levels were assessed to determine the treatments' effects. AgNPs + RV treatment significantly reduced pro-inflammatory cytokines, NF-κB activation, presepsin, PCT, 8-OHDG, and VEGF levels compared with the CLP group, indicating attenuation of sepsis-induced liver injury. Both RV and AgNPs + RV treatments increased SIRT1 levels, suggesting a potential role of SIRT1 activation in mediating the protective effects. In conclusion, AgNPs + RV treatment demonstrated extremely enhanced efficacy in alleviating sepsis-induced liver injury by modulating inflammation, oxidative stress, and endothelial dysfunction, potentially mediated through SIRT1 activation. In this study, the effect of AgNPs + RV on sepsis was evaluated for the first time, and these findings highlight AgNPs + RV as a promising therapeutic strategy for managing sepsis-induced liver injury, warranting further investigation. © Wolters Kluwer Health, Inc. All rights reserved.Lippincott Williams and Wilkins2023Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/11973https://doi.org/10.1097/shk.00000000000022181073-2322enShockinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/11973