2026-10-19T01:47:49Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/121062026-10-18T20:27:03Zopenairedrivercom_ebyu_10000col_ebyu_10001The Effect of Carvacrol on Oxidative and Inflammatory Liver Damage due to Staphylococcus aureus Infection in RatsDabanlioglu, BulentSuleyman, BahadirMammadov, RenadCoban, Taha AbdulkadirYazici, Gulce NazAkyuz, SumeyyeYavuzer, BulentBulut, SevalSuleyman, Haliscarvacrolcefazolinliver damageratStaphylococcus aureusalanine aminotransferaseaspartate aminotransferaseglutathioneimmunoglobulin enhancer binding proteininterleukin 1betamalonaldehydethiopentaltumor necrosis factoranimal experimentanimal modelanimal tissueantibacterial activityantibiotic sensitivityantiinflammatory activityantimicrobial activityantioxidant activityArticlebiochemical analysiscolony forming unitcontrolled studydisk diffusiondrug efficacydrug megadoseenzyme linked immunosorbent assayhistopathologySUMMARY. Staphylococcus aureus is a bacterial pathogen that can cause oxidative stress. Carvacrol has anti-microbial, antioxidant, anti-inflammatory and hepatoprotective effects. This study evaluated the antibacterial effect of carvacrol and its effect on liver damage by S. aureus. The rats were divided into four groups: con-trol(HG), S. aureus injected (SaG), S. aureus + carvacrol (SaC), and S. aureus + cefazolin (SaCF). S. aureus was injected intraperitoneally (ip) to the SaG, SaC and SaCF groups. 24 h after the injection, carvacrol was given to the SaC group and cefazolin to the SaCF group as ip. Carvacrol and cefazolin administration was continued for 7 days. According to our antibiogram results, although the antibacterial effect of carvacrol was weaker than cefazolin, it prevented the increase of malondialdehyde (MDA), aminotransferase (ALT), aspar-tate aminotransferase (AST) and proinflammatory cytokines and the decrease of total glutathione (tGSH) better (p < 0.001). It also managed histopathological damage better than cefazolin. The results indicate that carvacrol may be helpful in the treatment of liver damage from infection. © 2023, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.Colegio de Farmaceuticos de la Provincia de Buenos Aires2023Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/121060326-2383enLatin American Journal of Pharmacyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12106