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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/123102026-10-18T21:13:21Zopenairedrivercom_ebyu_10000col_ebyu_10001

Molecular mechanism of the protective effect of adenosine triphosphate against paracetamol-induced liver toxicity in ratsKoç, AlparslanGazi, MustafaCaner Sayar, AliOnk, DidemAli Arı, MuhammetSüleyman, BahadırGökhan Ağgül, AhmetAltındağ, FikretAltuner, DurduSüleyman, HalisATPLiver toxicityPainParacetamolAcetaminophenAdenosine TriphosphateAnimalsAntioxidantsChemical and Drug Induced Liver InjuryLiverOxidative StressRatscatalaseglutathionemalonaldehydesuperoxide dismutaseantioxidantalanine aminotransferase blood levelanimal experimentanimal modelanimal tissueArticleaspartate aminotransferase levelcontrolled studydrug mechanismedemaenzyme activityfibrosishistopathologylipid storageToxic doses of paracetamol are also known to be close to therapeutic doses. This study aimed to biochemically investigate the protective effect of ATP against paracetamol-induced oxida-tive liver injury in rats and to examine the tissues histopathologically. We divided the animals into the paracetamol alone (PCT), ATP + paracetamol (PATP), and healthy control (HG) groups. Liver tissues were examined biochemically and histopathologically. Malondialdehyde level, AST and ALT activity in the PCT group were significantly higher than those in the HG and PATP groups (p < 0.001). The glutathione (tGSH) level, superoxide dismutase (SOD) and catalase (CAT) activity in the PCT group was significantly lower than that in the HG and PATP groups (p < 0.001), while animal SOD activity was significantly different between the PATP and HG groups (p < 0.001). The activity of CAT was almost the same. In the group treated with paracetamol alone, lipid deposition, necrosis, fibrosis, and grade 3 hydropic degeneration were observed. No histopathological damage was observed of the ATP-treated group, except for grade 2 edema. We discovered that ATP reduces the oxidative stress caused by paracetamol ingestion and protects against paracetamol-induced liver injury at the macroscopic and histological levels. © The Authors 2023.Slovak Academy of Sciences2023Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12310https://doi.org/10.4149/gpb_20220550231-5882enGeneral Physiology and Biophysicsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12310