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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/123362026-10-18T20:56:43Zopenairedrivercom_ebyu_10000col_ebyu_10001

Efficacy of Topical Boric Acid in the Treatment of Experimental Pseudomonas Aeruginosa Keratitis in Rats; [Sıçanlarda Deneysel Pseudomonas Aeruginosa Keratiti Tedavisinde Topikal Borik Asitin Etkinliği]Ondas, OsmanUtlu, BahadirBayrakceken, KemalYildirim, SerkanBoric acidkeratitispseudomonas aeruginosaIntroduction: It was aimed to investigate the effect of topical boric acid on healing in the treatment of keratitis. Materials and Methods: Keratitis was created by randomly 32 of 56 healthy rats with inoculating pseudomonas aeruginosa (1x108 colony-forming units/ml 0.05 ml of solution containing pseudomonas eruginosa-PA-ATC27853) by creating epithelial defects in the corneas and randomly distributed to 4 groups. The remaining 24 healthy rats were randomly divided into 3 groups, so that; group 1 (control group), group 2 (with pseudomonas keratitis), group 3 (with pseudomonas keratitis and 4% boric acid treatment), group 4 (with pseudomonas keratitis and 8% boric acid treatment), group 5 (with pseudomonas keratitis and vancomycin+ ceftazidime given), group 6 (non-keratitis and only 4% boric acid applied), group 7 (non-keratitis and only 8% boric acid applied). At the end of the study, the ocular tissues of the rats were removed and examined histopathologically. Results: A clinically significant reduction in inflammation was detected in the groups using topical boric acid. Decreased TGF-β1 staining was detected in the groups in which keratitis + %4 and %8 boric acid was treated topically (p˂0,05). Compared to the infected group (group 2), 4% and 8% boric acid administered groups revealed mild/moderate corneal edema and thickening, degeneration of the corneal epithelium, and mild/moderate inflammation in the interstitial. Conclusion: Topical boric acid drops may be an important therapeutic factor in tissue healing and in the fight against inflammation in the treatment of keratitis. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Yuzuncu Yil Universitesi Tip Fakultesi2023Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12336https://doi.org/10.5505/vtd.2023.154251300-2694enVan Medical Journalinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12336