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Quadruple-Rule-Out Computed Tomography Angiography (QRO-CT): A Novel Dual-Energy Computed Tomography Technique for the Diagnostic Work-Up of Acute Chest PainCetin, TurkhunKantarci, MecitIrgul, BarisAydin, SonayAydin, FahriKoseturk, TanerLevent, AkinDECTemergencymyocarditisperfusion deficittriple rule outadultagedaortaaortic dissectionArticlecardiac gated imagingcardiovascular magnetic resonancecontrolled studycoronary artery circumflex branchcoronavirus disease 2019diagnostic accuracydiagnostic test accuracy studydual energy computed tomographyelectrocardiogramemergency wardfemalefollow upheart muscle perfusionhumanimage qualityleft anterior descending coronary arteryleft coronary arterylung embolismmajor clinical studymaleBackground: Computerized tomography (CT) has been increasingly utilized in the differential diagnosis of acute chest pain. Combining the triple rule out CT angiography (TRO-CT) approach with dual-energy CT (DECT) can enhance the diagnostic capability by identifying myocardial perfusion deficiencies. This combination can yield a quadruple-rule-out computed tomography angiography (QRO-CT) technique. The aim of this study is to determine the efficacy of the QRO-CT. Methods: Intraluminal diseases and abnormalities in the main coronary arteries and branches were investigated. The myocardial dark spots on the color-coded iodine map were identified as perfusion deficiencies. Pulmonary arteries and aorta were also evaluated. Results: The study population consisted of 211 patients. The sensitivity, specificity, and positive and negative predictive values of QRO-CT for pulmonary embolism were 93.5%, 100%, 100%, and 95.3%, respectively. For obstructive coronary artery disease, the values were 96.1%, 93.4%, 89.2%, and 97.7%, respectively. For myocarditis, the values were 69.2%, 100%, 100%, and 93.6%, respectively. Conclusions: the QRO-CT method may successfully evaluate myocardial perfusion deficits, hence expanding the differential diagnosis capabilities of the standard TRO-CT method for myocarditis. It can provide useful information on myocardial perfusion, which may influence the choice to perform invasive catheterization in cases of coronary artery obstruction. © 2023 by the authors.Multidisciplinary Digital Publishing Institute (MDPI)2023Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12356https://doi.org/10.3390/diagnostics131727992075-4418enDiagnosticsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12356