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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/124402026-10-18T20:43:18Zopenairedrivercom_ebyu_10000col_ebyu_10001

Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cellsAy, Ebru NurCaner, ArmağanÖzsoy Hepokur, CeylanDanişman Kalindemirtaş, FerdaneÖzen Eroğlu, GüneşKariper, İ. AfşinBreast cancercytotoxicitynanoparticlepropolisThe aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various methods were used to characterize the surface and morphology of propolis nanoparticles (NP-Pro), including UV-VIS, FTIR, DLS, and EDX-SEM. The cytotoxic activity of MCF-7, MDA-MB-231 breast cancer cells was measured by XTT technique and compared with healthy cells (MCF-10A). The apoptotic effect of NP-Pro was assessed by flow cytometry using Annexin/PI. The IC50 values of NP-Pro on MCF-7, MDA-MB-231 and MCF-10A cells were 13.67 ± 0.89, 17.89 ± 0.6, 29.9 ± 0.56 µg, respectively. According to these findings, the NP-Pro form we prepared was more cytotoxic on cancer cells than propolis. Cancer cells had much stronger apoptotic activity than healthy cells (p < 0.0001). In this work, NP-Pro was produced through a distinct, straightforward, and low-cost method. In summary, the NP-Pro we synthesized may be a promising potential agent for breast cancer treatment due to its specific cytotoxicity via apoptosis. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd.2023Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12440https://doi.org/10.1080/16583655.2023.22496281658-3655enJournal of Taibah University for Scienceinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12440