2026-10-19T00:02:03Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/124992026-10-18T21:13:20Zopenairedrivercom_ebyu_10000col_ebyu_10001

Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluationCerrah, SerkanAkbas, NergisOzcicek, FatihMammadov, RenadAltuner, DurduSuleyman, HalisBulut, Sevalaspirinbiochemicalgastric damagerattaxifolinAnimalsAntioxidantsFamotidineQuercetinRatsacetylsalicylic acidalanine aminotransferaseantioxidantglutathionepazopanibsuperoxide dismutaseanimal experimentanimal modelanimal tissueantiinflammatory activityantiulcer activityArticlebinding affinitybiochemical analysisbiochemistrycontrolled studyenzyme activityhematocrithistopathologylipid peroxidationTaxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those of famotidine. Rats were divided into four drug administration groups: a healthy control group, an aspirin-only group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). The results revealed that in light of the results that we obtained, 50 mg/kg taxifolin had anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers. © 2023 Japanese Association for Laboratory Animal Science.International Press Editing Centre Incorporation2023Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12499https://doi.org/10.1538/expanim.22-00651341-1357enExperimental Animalsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12499