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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/125122026-10-18T20:39:06Zopenairedrivercom_ebyu_10000col_ebyu_10001

Pregnancy-Associated Plasma Protein-A as an Inflammatory Biomarker in Patients Undergoing Coronary Artery Bypass SurgeryOnk, Oruç AlperOnk, DidemOzcelik, FatihGünay, Muratcardiac biomarkercoronary artery bypass graftingcoronary artery diseaseinterleukin 6pregnancy associated plasma protein Atumor necrosis factorvasculotropinagedArticleblood samplingcontrolled studycoronary angiographycoronary artery bypass graftcoronary artery obstructioncross-sectional studydisease severityhumanmajor clinical studymaleoutcome assessmentpreoperative periodStudy Objectives: Data is limited to show whether PAPA-A and/or VEGF are useful tests to predict the prognosis of coronary artery disease. We sought to investigate the potential roles of PAPP-A and VEGF in predicting the severity of coronary artery disease in patients undergoing coronary artery bypass grafting. Methods: A total of 212 male patients who were scheduled to undergo coronary angiography were included. Patients were divided into five groups. Group 0: Patients with normal coronary arteries, Group 1: Patients with <50% stenosis in only one coronary artery, Group 2: Patients with >50% stenosis in 1 or 2 coronary arteries, Group 3: Patients with >50% stenosis in 3 or 4 coronary arteries, Group 4: Patients with >50% stenosis in 5 or more coronary arteries. PAPP-A, TNF-α, IL-6, and VEGF, blood samples were centrifuged at a rate of 3500 rpm for 10 minutes. Results: In the preoperative measurements, all inflammatory biomarkers except VEGF were significantly associated with an increasing number of diseased coronary arteries where hsCRP and PAPP-A showed the highest level of association. In the 7th postoperative day measurements, only PAPP-A and IL-6 showed significant association with the dependent outcome. PAPP-A was found to be associated with an increased risk of a higher number of diseased coronary arteries. Conclusion: PAPP-A offers a useful tool in the diagnosis of the severity of coronary artery involvement in patients undergoing CABG. Its use alone or in combination with TNF- α and/or CRP may potentially distinguish patients with and without advanced disease. © Mattioli 1885Mattioli 18852022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12512https://doi.org/10.23751/pn.v24is1.129501129-8723enProgress in Nutritioninfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12512