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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/126052026-10-18T21:13:28Zopenairedrivercom_ebyu_10000col_ebyu_10001

Effects of prenatal and lactational bisphenol a and/or di(2-ethylhexyl) phthalate exposure on male reproductive systemBalcı, AylinÖzkemahlı, GizemErkekoglu, PınarZeybek, DilaraYersal, NilgünKocer-Gumusel, BelmaBisphenol Aendocrine disruptorsphthalatereproductive systemAnimalsBenzhydryl CompoundsDiethylhexyl PhthalateFemaleGenitalia, MaleLactationMalePhenolsPhthalic AcidsPregnancyPrenatal Exposure Delayed EffectsRatsRats, Sprague-Dawley4,4' isopropylidenediphenolphthalic acid bis(2 ethylhexyl) esterbenzhydryl derivativeendocrine disruptorphenol derivativephthalic acidphthalic acid derivativereproductive phenomenaanimal experimentArticlecontrolled studylactational exposuremale genital systemBisphenol A (BPA) and phthalates are abundantly used endocrine disrupting chemicals (EDCs). The aim of this study was to evaluate the effects of single and combined exposures to BPA and/or di(2-ethylhexyl) phthalate (DEHP) in prenatal and lactational period on rat male reproductive system in later stages of life. Pregnant Sprague-Dawley rats were divided randomly to four groups (n = 3/group): Control (corn oil); DEHP (30 mg/kg/day); BPA (50 mg/kg/day); and BPA+ DEHP (30 mg/kg/day DEHP and 50 mg/kg/day BPA). Groups exposed to EDCs through 6–21 gestational days and lactation period by intragastric lavage. Male offspring (n = 6/group) from each mother were fed till adulthood and were then euthanized. Later, reproductive hormones, sperm parameters, and oxidative stress parameters were determined. In conclusion, we can suggest that prenatal and lactational exposure to BPA and DEHP may cause adverse effects in male reproductive system in later stages of life especially after combined exposure. © 2020 Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd.2022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12605https://doi.org/10.1080/09603123.2020.18054160960-3123enInternational Journal of Environmental Health Researchinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12605