2026-10-19T01:08:10Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/126262026-10-18T21:13:24Zopenairedrivercom_ebyu_10000col_ebyu_10001

A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological studyUn, HarunUgan, Rustem AnilKose, DuyguYayla, MuhammedTastan, Tugba BalBayir, YasinHalici, ZekaiCecal ligation and punctureInflammationRasagilineRatSepsisAcute Lung InjuryAnimalsCecumDisease Models, AnimalIndansLigationOxidative StressRatsRats, Sprague-Dawleyglutathionehigh mobility group B1 proteinimmunoglobulin enhancer binding proteininterleukin 1betainterleukin 6malonaldehydesevofluranesuperoxide dismutasethiopentaltumor necrosis factorindan derivativeanimal experimentanimal modelanimal tissueantiinflammatory activityantioxidant activityAim: We aimed to investigate the effects of rasagiline on acute lung injury that develops in the sepsis model induced with the cecal ligation and puncture in rats. Main Methods: The rats were separated into the following six groups, Group 1: Sham, Group 2: Sham + Rasagiline 4 mg/kg, Group 3: Sepsis, Group 4: Sepsis + Rasagiline 1 mg/kg, Group 5: Sepsis + Rasagiline 2 mg/kg, Group 6: Sepsis + Rasagiline 4 mg/kg. A total of four holes were opened with a 16-gauge needle through the cecum distal to the point of ligation. Key Findings: Rasagiline treatment increased glutathione level and superoxide dismutase activity while decreased the malondialdehyde level after the sepsis. There was a statistically significant improvement in the doses of 2 mg/kg and 4 mg/kg. Rasagiline also increased Tnf-α, IL1β, IL6, NF-κβand HMGB1 gene expressions in dose-dependent at 2 mg/kg and 4 mg/kg doses. In increased doses, rasagiline prevent the development of edema, the formation of inflammation, and hemorrhage. Significance: Rasagiline exerts both antioxidant and anti-inflammatory effects on the cecal ligation and puncture induced acute lung injury in rats. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.Springer Science and Business Media B.V.2022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12626https://doi.org/10.1007/s11033-022-07235-10301-4851enMolecular Biology Reportsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12626