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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/126442026-10-18T21:13:25Zopenairedrivercom_ebyu_10000col_ebyu_10001

C entella asiatica extract protects against cisplatin-induced hepatotoxicity via targeting oxidative stress, inflammation, and apoptosisFerah Okkay, IrmakOkkay, UfukAydin, Ismail CagriBayram, CemilErtugrul, Muhammed SaitMendil, Ali SefaHacimuftuoglu, AhmetApoptosisCentella asiaticaCisplatinHepatotoxicityInflammationOxidative stressAnimalsAntioxidantsCentellaChemical and Drug Induced Liver InjuryLiverPlant ExtractsRatsTriterpenesantioxidantCentella asiatica extractplant extracttriterpeneherbhistopathologyinduced responseinhibitioninjurytoxicityanimalmetabolismrattoxic hepatitisThis study was designed to investigate the protective effects of Centella asiatica (CA) on cisplatin-induced hepatotoxicity and to clarify the underlying mechanism by biochemical, molecular, immunohistochemical, and histopathological analyses. Rats were pre-treated with two doses of CA (100 and 200 mg/kg, p.o.) for 14 consecutive days. Then, on the 15th day, hepatotoxicity was induced by a single cisplatin injection (10 mg/kg i.p.). On the 18th day, the rats were euthanized. CA effectively alleviated cisplatin-induced hepatic injury via reduction in AST, ALT, and ALP enzymes and a decrease in oxidative stress (decreased MDA and ROS, and increased SOD, CAT, and GSH). CA also mitigated the inflammatory damage by the inhibition of TNF-α, IL-1β, and NF-κB. The liver expression of caspase-3 and Bax was downregulated, while Bcl-2 was upregulated. Moreover, immunohistochemical results confirmed the recovery with CA by downregulation of iNOS and 8-OHdG expression. These results showed that with its antioxidant, anti-inflammatory, and anti-apoptotic activities, CA could help alleviate the hepatotoxic effects of cisplatin chemotherapy. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Springer Science and Business Media Deutschland GmbH2022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12644https://doi.org/10.1007/s11356-022-18626-z0944-1344enEnvironmental Science and Pollution Researchinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12644