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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/126962026-10-18T21:13:24Zopenairedrivercom_ebyu_10000col_ebyu_10001

First-line treatment of patients with HER2-positive metastatic gastric and gastroesophageal junction cancerEsen, Selin AktürkErgun, YakupErol, CihanArikan, RukiyeEr, Muhammed MuhiddinAtci, Muhammed MustafaTopçu, AtakanUçar, GökhanAkagündüz, BaranAykan, Musa BarişÖzen, MiraçBaytemur, Naziyet KöseÖzçelik, MelikeŞahin, ElifGüven, DenizcanMenekşe, SerkanAk, NaziyeTeker, FatihKut, EnginŞakalar, TeomanAlan, ÖzkanKaçan, TurgutTurhal, Nazim SerdarKiliçkap, SaadettinTürker, SemaŞendur, Mehmet Ali NahitKöstek, OsmanKaraağaç, MustafaSakin, AbdullahTürk, Haci MehmetÇağlayan, DilekCihan, ŞenerAçikgöz, YusufUncu, DoğanCFFOLFOXgastric cancergastroesophageal junction cancertrastuzumabAntineoplastic Combined Chemotherapy ProtocolsCisplatinEsophageal NeoplasmsEsophagogastric JunctionFluorouracilHumansLeucovorinMiddle AgedOxaliplatinReceptor, ErbB-2Retrospective StudiesStomach Neoplasmsantineoplastic agentepidermal growth factor receptor 2folinic acidclinical trialesophagus tumorgastroesophageal junctionhumanmulticenter studypathologyretrospective studystomach tumorFluoropyrimidine+cisplatin/oxaliplatin+trastuzumab therapy is recommended for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic gastric adenocarcinoma. However, there is no comprehensive study on which plati-num-based treatment should be preferred. This study aimed to compare the treatment response and survival characteristics of patients with HER2-positive metastatic gastric or gastroesophageal junction (GEJ) cancer who received f luorouracil, oxaliplatin, and leucovo-rin (mFOLFOX)+trastuzumab or cisplatin and f luorouracil (CF)+trastuzumab as first-line therapy. It was a multicenter, retrospective study of the Turkish Oncology Group, which included 243 patients from 21 oncology centers. There were 113 patients in the mFOLF-OX+trastuzumab arm and 130 patients in the CF+trastuzumab arm. The median age was 62 years in the mFOLFOX+trastuzumab arm and 61 years in the CF+trastuzumab arm (p = 0.495). About 81.4% of patients in the mFOLFOX+trastuzumab arm and 83.1% in the CF+trastuzumab arm had gastric tumor localization (p = 0.735). The median progression-free survival (PFS) was significantly higher in the mFOLFOX+trastuzumab arm (9.4 months vs. 7.3 months, p = 0.024). The median overall survival (OS) was similar in both groups (18.4 months vs. 15.1 months, p = 0.640). Maintenance trastuzumab was continued after chemotherapy in 101 patients. In this subgroup, the median OS was 23.3 months and the median PFS was 13.3 months. In conclusion, mFOLFOX+trastuzumab is similar to CF+trastuzumab in terms of the median OS, but it is more effective in terms of the median PFS in the first-line treatment of HER2-positive metastatic gastric and GEJ cancer. The choice of treatment should be made by considering the prominent toxicity findings of the chemotherapy regimens. © The Author(s) (2022).Association of Basic Medical Sciences of FBIH2022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12696https://doi.org/10.17305/bjbms.2021.70691512-8601enBosnian Journal of Basic Medical Sciencesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12696