2026-10-19T00:27:38Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/128832026-10-18T21:13:29Zopenairedrivercom_ebyu_10000col_ebyu_10001Can zaprinast and avanafil induce the levels of angiogenesis, bone morphogenic protein 2, 4 and 7 in kidney of ovariectomised rats?Huyut, ZübeyirBakan, NuriYıldırım, SerkanAkbay, Halil İbrahimHuyut, Mehmet TahirAhlatçı, AdemUçar, BünyaminAngiogenesisavanafilbone morphogenetic proteinphosphodiesterase-5 inhibitorzaprinastAnimalsFemaleHumansKidneyOvariectomyPurinonesPyrimidinesRatsVascular Endothelial Growth Factor Apurine derivativepyrimidine derivativevasculotropin AanimalhumanmetabolismratObjective: This study investigated effects of zaprinast and avanafil on angiogenesis, vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 2, 4 and 7. Methods: Female rats were randomly divided into four groups (n = 6). Sham; abdomen was approximately 2 cm opened and closed. Ovariectomised (OVX); abdomen was opened 2 cm and the ovaries were cut. OVX + zaprinast and OVX + avanafil groups; after the same procedure with OVX, 10 mg/kg zaprinast and avanafil were orally administered for 2 month, respectively. Angiogenesis and the levels of VEGF, BMP2, 4 and 7 were determined. Results: VEGF, BMP2, 4 and 7 levels in OVX + zaprinast and especially OVX + avanafil groups were higher than the sham and OVX (p <.05). However, only VEGF and BMP2 levels in OVX + zaprinast group were significant according to sham (p <.05). Also, angiogenesis in OVX + zaprinast and OVX + avanafil groups was dominant according to sham and OVX (p <.05). Conclusions: Zaprinast and avanafil induced BMP2, 4 and 7 levels synergistically with increased VEGF and angiogenesis in renal tissue. © 2020 Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd.2022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12883https://doi.org/10.1080/13813455.2020.17407431381-3455enArchives of Physiology and Biochemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12883