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The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunctionDelen, Leman AcunDişli, Zeliha KorkmazTaş, Hakan G.Kuyrukluyildiz, UfukYazici, Gulce N.Süleyman, BahadirKuzucu, MehmetGürsu, CebrailSuleyman, HalisAntioxidantsLiverOxidative stressPropofolThiamine pyrophosphateAlanine TransaminaseAnimalsAspartate AminotransferasesGlutathioneMalondialdehydeRatsRats, Wistaralanine aminotransferaseaspartate aminotransferasecocarboxylaselactate dehydrogenasemalonaldehydeoxidizing agentantioxidantalanine aminotransferase blood levelanimal experimentanimal modelanimal tissueArticleaspartate aminotransferase blood levelcontrolled studydrug effectepitheliumhistopathologyliver dysfunctionPropofol may cause an increase in reactive oxygen species in the body. In this study, we tested the effect of antioxidant thiamine pyrophosphate (TPP) on propofol-induced liver damage. The eighteen rats were split into three groups: HG, healthy; PP, propofol-treated (50 mg/kg) and PT, treated with propofol (50 mg/kg) and TPP (25 mg/kg). Total glutathione (tGSH), total oxidant (TOS), and total antioxidant (TAS) levels were tested together with aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and malondialdehyde (MDA). Histopathological examination of the tissues was performed. We have found that levels of MDA, TOS, ALT, AST, and LDH were all higher in PP group than in HG and PT groups (p < 0.05). In PP group, the TAS and tGSH levels were statistically substantially lower. The PT for oxidants levels showed a statistically significant reduction. In PT group, the levels of antioxidants were found to be considerably higher. The epitheliums, glands, and vascular structures of the PTs were histologically close to normal. By boosting antioxidants, TPP may help to reduce propofol-induced liver damage. © The Authors 2022.Slovak Academy of Sciences2022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12952https://doi.org/10.4149/gpb_20210430231-5882enGeneral Physiology and Biophysicsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12952