2026-10-18T23:47:43Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/129602026-10-18T20:41:30Zopenairedrivercom_ebyu_10000col_ebyu_10001Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in ratColluoglu, CagdasBalci, SerdarGundogdu, BetulCoban, Taha AbdulkadirBulut, SevalSuleyman, HalisTOXICITYSTRESSANTIOXIDANTSGLUTATHIONEINFERTILITYEXTRACTTISSUEOXYGENACIDPharmacology & PharmacyThis study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclo-phosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examina-tions were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone atte-nuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage. © 2022, Bangladesh Pharmacological Society. All rights reserved.Bangladesh Pharmacological Society2022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/12960https://doi.org/10.3329/bjp.v17i3.594181991-007XenBangladesh Journal of Pharmacologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/12960