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Changes in antimicrobial resistance and outcomes of health care–associated infectionsAydın, MehtapAzak, EmelBilgin, HüseyinMenekse, SirinAsan, AliMert, Habibe Tülin ElmaslarYulugkural, ZerrinAltunal, Lutfiye NilsunHatipoğlu, Çiğdem AtamanTuncer Ertem, GunayAltunok, Elif SargınDemirkaya, Melike HamiyetÇeviker, Sevil AlkanAkgul, FethiyeMemis, ZeynepKonya, PetekAzap, AlpayAydin, GuleKorkmaz, DeryaKarakoç, Zehra ÇaglaYapar, DeryaKarakecili, FarukGunal, OzgurKeske, SiranKapmaz, MahirKader, CigdemDemirel, AslıhanErgönül, Önderassociated infectionsBlood stream infectionsColistin resistanceHealth careAnti-Bacterial AgentsAntifungal AgentsBacteremiaBacteriaBacterial InfectionsCandidaCross InfectionDrug Resistance, BacterialFungemiaHumansMycosesRetrospective Studiescarbapenemcolistinmeticillinquinolonevancomycinantifungal agentantiinfective agentmycosisAcinetobacteradultantibiotic resistanceArticlebloodstream infectioncandidiasisTo describe the change in the epidemiology of health care–associated infections (HAI), resistance and predictors of fatality we conducted a nationwide study in 24 hospitals between 2015 and 2018. The 30-day fatality rate was 22% in 2015 and increased to 25% in 2018. In BSI, a significant increasing trend was observed for Candida and Enterococcus. The highest rate of 30-day fatality was detected among the patients with pneumonia (32%). In pneumonia, Pseudomonas infections increased in 2018. Colistin resistance increased and significantly associated with 30-day fatality in Pseudomonas infections. Among S. aureus methicillin, resistance increased from 31 to 41%. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.Springer Science and Business Media Deutschland GmbH2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13021https://doi.org/10.1007/s10096-020-04140-y0934-9723enEuropean Journal of Clinical Microbiology and Infectious Diseasesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13021