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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/130282026-10-18T20:27:52Zopenairedrivercom_ebyu_10000col_ebyu_10001

The effect of adenosine triphosphate on oral mucosity in rats due to sunitinib administrationDilber, MuhammetSalcan, IsmailBayram, RanaSuleyman, EsmaYildirim, UgurSonmez, FaikBakan, EbubekirCoban, Taha AbdulkadirSuleyman, ZeynepSuleyman, HalisAdenosine triphosphateCheekOral mucositisOxidative damageSunitinib2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid)bevacizumabbutanolformic acidglutathionehydrogen peroxidemalonaldehydeprotein tyrosine kinase inhibitorpyridinethiobarbituric acidthiobarbituric acid reactive substancethiopentalvasculotropinanimal experimentanimal modelanimal tissueantioxidant activityArticlebiochemical analysisbiochemistrycancer therapycontrolled studyDNA damagedrug effectevoked brain stem auditory responseSunitinib, a common drug used in cancer treatment, is a multi-targeted tyrosine kinase in-hibitor. It is argued that sunitinib-associated oral mucositis is caused by VEGF inhibition. Previous research has documented that ATP allows for wound healing through an increase in VEGF levels and pro-vides an antioxidant effect. The aim of our study was to biochemically analyze whether adenosine triphos-phate (ATP) offers any protective effects against potential oral oxidative mucosal damage due to sunitinib use in male albino Wistar rats. ATP was injected ip at 25 mg/kg dose to sunitinib + ATP(SAT) (n=8) group. Normal saline (0.9% NaCl) was applied in the same route to the sunitinib-alone(SUN) (n=8) and healthy (HG) (n=8) groups as the solvent. One hour after ATP and 0.9% NaCl were administered, oral de-livery of 25 mg/kg sunitinib was given to the SAT and SUN groups, once a day for four weeks. While MDA, TOS and 8-OHdG levels were significantly higher (p < 0.001) compared to the healthy and ATP group in the oral cavity tissues of subjects treated with sunitinib, tGSH and TAS were significantly lower (p < 0.001). Our experimental results show that ATP protects tongue and cheek tissues of rats from oxida-tive damage of sunitinib, indicating that ATP may be beneficial for sunitinib-related oral mucosal injury. © 2021, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.Colegio de Farmaceuticos de la Provincia de Buenos Aires2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/130280326-2383enLatin American Journal of Pharmacyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13028