2026-10-19T01:04:23Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/130552026-10-18T20:41:12Zopenairedrivercom_ebyu_10000col_ebyu_10001Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in ratsKiremitli, SevilKiremitli, TunayNayki, UmitYilmaz, NesrinTurkler, CanDinc, KemalMammadov, RenadYazici, GulceGulaboglu, MineCetin, NihalAntioxidantsIschemia-reperfusionOvarian damageOvarian torsionOxidative stressRatTaxifolinObjective: To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in rats. Methods: A total of 18 female Wistar albino rats were randomly and equally divided into three groups: the sham group, the ovarian ischemia reperfusion group, and the 50 mg/kg taxifolin+ovarian ischemia reperfusion group. The ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion protocol. Biochemical and histopathologic examinations were performed on the extracted ovaries. Results: Levels of malondialdehyde and cyclooxygenase-2 were increased, while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion group. However, these values were reversed in the taxifolin+ovarian ischemia reperfusion group. Similarly, the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group, while they were within normal range in the taxifolin+ovarian ischemia reperfusion group. Conclusions: Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury, and taxifolin may be useful for protecting ovarian tissue from such injury. © 2021 Asian Pacific Journal of Reproduction Produced by Wolters Kluwer- Medknow. All rights reservedWolters Kluwer Medknow Publications2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13055https://doi.org/10.4103/2305-0500.3211242305-0500enAsian Pacific Journal of Reproductioninfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13055