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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/130772026-10-18T21:13:27Zopenairedrivercom_ebyu_10000col_ebyu_10001

Highly efficient chemical phosphorylation of 6-(4-phenylpiperazine-1-yl)-9-(β-D-ribofuranosyl)-9H-purinePolat, M. FatihTuncbilek, Meralmicrowave-assisted synthesisNucleoside-5’-O-phosphate analogphosphorylationModels, MolecularMolecular ConformationPurine NucleosidesStereoisomerism6 (4 phenylpiperazine 1 yl) 9 (2',3' o isopropylidene 5' o (i tert butyl)phosphoryl beta dextro ribofuranosyl) 9h purine6 (4 phenylpiperazine 1 yl) 9 (2,3,5 tri o acetyl beta dextro ribofuranosyl) 9h purine6 (4 phenylpiperazine 1 yl) 9 (beta dextro ribofuranosyl) 9h purine6 (4 phenylpiperazine 1 yl) 9 (beta dextro ribofuranosyl) 9h purine 5'o phosphate6 (4 phenylpiperazine 1 yl] 9 (2',3'o isopropylidene beta dextro ribofuranosyl) 9h purine6 chloro 9 (2,3,5 tri o acetyl beta dextro ribofuranosyl) 9h purinepurine derivativeunclassified drugpurine nucleosideArticlecontrolled studydrug synthesismicrowave radiationchemistryconformationmolecular modelAntimetabolites, which are metabolic antagonists used in the treatment of cancer and viral diseases by replacing metabolites, inhibit the action of metabolic enzymes and disrupt the pathways of synthesis of structural units necessary for the formation of nucleic acids. Purine antagonists, that are subunits of antimetabolites, reduce the production of purine bases, and hence, cause the nucleotide production to stop and bring about the death of cancer cells. Fludarabine (2-fluoro-ara-AMP), which is used in chemotherapy, is an antimetabolite of the purine class containing mono phosphate in its structure. In this study, a protocol was presented to effectively and efficiently synthesis of 6-(4-phenylpiperazine-1-yl)-9-(β-D-ribofuranosyl)-9H-purine-5’- O-phosphate compound in six steps and 25% overall yield starting with commercially available 6-chloropurine. © 2021 Taylor & Francis Group, LLC.Bellwether Publishing, Ltd.2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13077https://doi.org/10.1080/15257770.2020.18436791525-7770enNucleosides, Nucleotides and Nucleic Acidsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13077