2026-10-19T02:47:30Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/131302026-10-18T20:56:45Zopenairedrivercom_ebyu_10000col_ebyu_10001Isolation, characterization and antiproliferative activity of secondary metabolites from tanacetum alyssifolium (Bornm.) griersonKöksal, EkremUlutaş, YakupŞimşek, SamedBayraktar, TahaAltay, AhmetÇatır, MustafaDemirtaş, İbrahimTüfekçi, Ali RızaKandemir, AliAlp, CemalettinAnwer Alemdar, Mohammed B.Akşit, HüseyinCytotoxicityMCF-7 cell lineSesquiterpene lactonesTanacetum alyssifolium2,4 dihydroxy 6 methoxy acetophenoneacetophenone derivativealtissinaxillarincoumarin derivativedoxorubicindrug metaboliteflavonoidfraxetinfraxidinisofraxidinisofraxidin 7 glucosideluteolin 7 glucosidepiceinrutosidesesquiterpene lactonetamirintanachintatridin Aunclassified drugaerial plant partantiproliferative activityArticlecontrolled studydrug isolationdrug structureSecondary metabolites of Tanacetum alyssifolium (Bornm.) Grierson (Asteraceae) were investigated for the first time. Thirteen compounds including axillarin (1), Luteolin-7-O-β-glucoside (8) and rutin (13) as flavonoids, fraxetin (7), isofraxidin (9), isofraxidin-7-O-glucoside (11) and fraxidin (12) as coumarins, tatridin A (2), altissin (3), tamirin (4) and tanachin (5) as sesquiterpene lactones and 2,4-dihydroxy-6-methoxy acetophenone (6) and picein (10) as acetophenone derivatives were isolated from the methanol extract of the species. The structures of all isolated compounds were elucidated by 1D and 2D-NMR techniques and by comparing with the literature data. In addition, in vitro cytotoxic activity of all isolated compounds was evaluated against breast cancer MCF-7 cell line by XTT assay. Sesquiterpene lactones; tatridin A (2), tamirin (4) and tanachin (5) were found to be the most cytotoxic molecules against MCF-7 cell line. © 2020 ACG Publications.ACG Publications2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13130https://doi.org/10.25135/rnp.201.20.07.17021307-6167enRecords of Natural Productsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13130