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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/131362026-10-18T21:13:05Zopenairedrivercom_ebyu_10000col_ebyu_10001

Protection against experimental cisplatin-induced optic nerve toxicity using resveratrol: A rat model studyAgcayazi, Sümeyye BurcuUgurlu, AdemUcak, TurgayTasli, Nurdan GamzeKarakurt, YucelIcel, ErelKeskin Cimen, FerdaSüleyman, Haliscisplatinoptic nerveResveratroltoxicityAnimalsDisease Models, AnimalHumansMaleNeuroprotective AgentsOptic Nerve InjuriesOxidative StressRatsantioxidantglutathioneimmunoglobulin enhancer binding proteinmalonaldehydeoxidizing agentthiopentaltumor necrosis factorneuroprotective agentanimal experimentanimal modelanimal tissueantiinflammatory activityantioxidant activityArticlebleedingblood vessel injuryblood vessel occlusioncapillary proliferationAim: To investigate the effects of resveratrol on oxidative stress and inflammation parameters and histological alterations in cisplatin-induced optic nerve damage in a mouse model. Material and Method: Thirty-six albino Wistar male rats were divided into three groups as control, 5 mg/kg cisplatin-administered (Cis) and 5 mg/kg cisplatin + 25 mg/kg resveratrol-administered (Cis + Res) animals. At the end of the experimental period, the rats were sacrificed with high-dose (50 mg/kg) thiopental sodium, and their optic nerves were dissected. Malondialdehyde (MDA), total glutathione (tGSH), total oxidant status (TOS), total antioxidant status (TAS), tumour necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-KB) levels, and histopathological findings were assessed using the optic nerve tissues. Results: In the Cis + Res group, the MDA, TOS, OSI, TNF-a and NFK-B levels were significantly lower and the tGSH and TAS levels were significantly higher compared with the Cis group (P = 0.001). In histological evaluations, there were dilated and congested blood vessels, destruction, oedema, degeneration, haemorrhage, and proliferating capillaries indicating the presence of inflammation and damage only in the Cis-administered group. However, in the Cis + Res group, the histological findings were very similar to the healthy controls. Conclusion: Resveratrol is a promising neuroprotective agent for cisplatin-induced optic nerve toxicity with its anti-oxidant and anti-inflammatory effects. Further investigations are needed to evaluate the possible therapeutic effects on other optic nerve toxicities. © 2021 Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd.2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13136https://doi.org/10.1080/15569527.2021.19401951556-9527enCutaneous and Ocular Toxicologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13136