2026-10-19T01:55:55Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/132552026-10-18T20:33:50Zopenairedrivercom_ebyu_10000col_ebyu_10001Synthesis, characterization and biological activity evaluation of novel naphthalenylmethylen hydrazine derivatives as carbonic anhydrase inhibitorsShirinzadeh, HanifDilek, EsraCarbonic anhydraseEnzyme inhibitionFNICKFVHHJDGAT-UHFFFAOYSA-NLMSLPMMHNMFLHP-UHFFFAOYSA-NLRSPBPNYAZMQFT-UNOMPAQXSA-NNaphthalenylmethylen hydrazineQBEFRSDYCFCLQT-UHFFFAOYSA-NSynthesisTVSPUNGBTKHUFA-UHFFFAOYSA-NUAIVSWGFFGHSMW-UHFFFAOYSA-NUUAOQBZZPLCVHT-UHFFFAOYSA-NVGPSXAJHUXUYBG-UHFFFAOYSA-NBioactivityCondensation reactionsHydrazineIsoenzymesCytosolicHydrazine derivativesInhibitory effectMedical areasPharmaceutical industryPhenylhydrazinePotent inhibitorSchiff basisIn the current study some derivatives of naphthalenylmethylen hydrazine were synthesized and possible in vitro hCA I and II enzymes inhibition effects were investigated. The designed compounds were synthesized by condensation of phenylhydrazine with 1-naphthaldehyde or 6-methoxy-2-naphthaldehyde and eight compounds (1a-h) were obtained. The novel Schiff bases derivatives (compounds 1a-1h) were effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II) with Ki values in the range of 80.60 ± 17.90 to 492.53 ± 95.23 nM for hCA I, 102.88 ± 18.44 to 461.09 ± 102.50 nM for hCA II. 1f compound shows a remarkable inhibitory effect of hCA I and hCA II isoenzymes among the new synthesized compounds. The new derivatives of naphthalenylmethylen hydrazine can be a potent inhibitor of both cytosolic CA isoenzymes which are commonly used in the pharmaceutical industries and medical areas. © 2020 Elsevier B.V.Elsevier B.V.2020Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13255https://doi.org/10.1016/j.molstruc.2020.1286570022-2860enJournal of Molecular Structureinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13255