2026-10-19T00:02:23Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/132652026-10-18T21:13:27Zopenairedrivercom_ebyu_10000col_ebyu_10001

Evaluation of the mir-126, mir-182, and mir-486-5p expression signature of head and neck squamous cell carcinomas and lung squamous cell carcinomasIssin, GizemKucukodaci, ZaferYilmaz, IsmailErkul, EvrenTural, ErsinDemirel, DilaverGungor, AtilaYildirim, SukruHead and neckLungMir-126Mir-182Mir-486-5pSquamous cell carcinomaAdultAgedAged, 80 and overBiomarkers, TumorFemaleGene Expression ProfilingHead and Neck NeoplasmsHumansLung NeoplasmsMaleMicroRNAsMiddle AgedReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionSquamous Cell Carcinoma of Head and NeckTranscriptomemicroRNAmicroRNA 126microRNA 182microrna 486 5psmall nuclear ribonucleoproteinunclassified drugMIRN126 microRNA, humanMirn182 microRNA, humanObjective: Although squamous cell carcinomas (SCCs) originating from different anatomic localizations display a similar histological appearance under light microscopy, they may differ in terms of epigenetic and genetic features. The aim of this study was to analyze mir-126, mir-182, and mir-486-5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles. Material and Method: The expression levels of mir-126, mir-182, and mir-486-5p were analyzed in lung, oral cavity, laryngeal, and hypopharyngeal SCCs in 40 patients, using quantitative real-time polymerase chain reaction. Results: The findings showed that lung, oral cavity, laryngeal, and hypopharyngeal SCCs have distinct mir-126 and mir-486-5p expression profiles. It was also observed that mir-126 and mir-486-5p expression levels were highly specific to the tumor localization. Conclusion: These findings highlighted that SCCs originating from different anatomic localizations have different miRNA expression profiles. miRNA expression analysis can be used to predict the primary localizations of those SCCs. © 2021, Federation of Turkish Pathology Societies. All rights reserved.Federation of Turkish Pathology Societies2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13265https://doi.org/10.5146/tjpath.2021.015281018-5615enTurk Patoloji Dergisiinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13265