2026-10-19T01:04:25Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/132902026-10-18T21:13:27Zopenairedrivercom_ebyu_10000col_ebyu_10001Activation of cannabinoid 2 receptors by JWH-133 protects against ovarian ischemia-reperfusion injury in ratsOnat, TaylanDemir Caltekin, MelikeDoğanyigit, ZüleyhaTurkler, CanKaymak, EminKara, MustafaSerdar Yalvac, EthemCannabinoid 2 receptorsinflammationischemia-reperfusion injuryJWH-133oxidative stressAnimalsCannabinoidsFemaleMalondialdehydeRatsRats, WistarReceptors, CannabinoidReperfusion Injury1,1-dimethylbutyl-1-deoxy-Delta(9)-THCcannabinoidcannabinoid receptormalonaldehydeanimalratWistar ratWe investigated the efficacy of activated cannabinoid 2 receptors for alleviating ovarian ischemia-reperfusion injury in rats. Female Wistar albino rats were divided randomly into six groups: ischemia-reperfusion (IRG); ischemia-reperfusion + 0.2 mg/kg JWH-133 (JIRG1), ischemia-reperfusion + 1 mg/kg JWH-133 (JIRG2); ischemia-reperfusion + 5 mg/kg JWH-133 (JIRG3); solvent control, and sham control. Ovarian ischemia was established for 3 h followed by reperfusion for 3 h. Ovarian tissue was investigated using histology, immunohistochemistry and biochemistry. Administration of JWH-133 synthetic cannabinoid reduced nuclear factor kappa-B immunoreactivity as well as TUNEL positivity scores and malondialdehyde levels. These reductions were significant in all cases except for the malondialdehyde levels in the 1 mg/kg JWH-133 group. Activation of cannabinoid 2 receptors by JWH-133 reduced ovarian ischemia-reperfusion injury due to its antioxidant and anti-inflammatory effects. © 2021 The Biological Stain Commission.Taylor and Francis Ltd.2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13290https://doi.org/10.1080/10520295.2021.19051831052-0295enBiotechnic and Histochemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13290