2026-10-19T01:08:42Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/133882026-10-18T20:39:09Zopenairedrivercom_ebyu_10000col_ebyu_10001

The association of MCP-1 level and MCP-1 -2518 A/G and CCR2 190 G/A gene polymorphisms with COPD and pulmonary hypertension; [MCP-1 düzeyi ve MCP-1 -2518 A/G ve CCR2 190 G/A Gen Polimorfizmlerinin KOAH ve Pulmoner Hipertansiyon ile İlişkisi]Yıldırım, Malik EjderBerk, SerdarKurtulgan, Hande KüçükTekin, GülaçanTekin, Yusuf KenanBaşer, BurakBağcı, GökhanErşan, SerpilKılıçgün, HasanCCR2COPDMCP-1PolymorphismPulmonary hypertensionchemokine receptor CCR2monocyte chemotactic protein 1adultalleleArticlechronic obstructive lung diseasecontrolled studyenzyme linked immunosorbent assayfemalegene frequencygenetic associationgenotypehumanhuman tissuemajor clinical studymaleprotein blood levelprotein expressionrestriction fragment length polymorphismObjective: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by obstructed airflow in the lungs. Pulmonary hypertension (PH) is a common complication of COPD and it is associated with pulmonary vascular remodelling. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines associated with migration of monocytes and macrophages. Both MCP-1 and its receptor CCR2 have been declared to be involved in various diseases. We aimed to research a possible association of MCP-1 level, MCP-1 -2518 A/G and CCR2 190 A/G polymorphisms with COPD and pulmonary hypertension in this study. Material and methods: Eighty patients and eighty controls were included in the study. Serum MCP-1 levels were measured by ELISA method. Restriction fragment length polymorphism (RFLP) procedure was used to detect the genotypes of patients and control group. Results: MCP-1 levels were found to be significantly higher in COPD patients than in healthy controls (P=0.001) and patients with COPD + PH had higher serum MCP-1 levels than COPD patients (P=0.005). No association was found between MCP-1/CCR2 gene polymorphisms and patient groups (COPD and COPD + PH). Conclusion: MCP-1 level seems to be associated with both COPD and pulmonary hypertension. Increased MCP-1 expression may most likely to be involved in the pathogenesis of these diseases. © Copyright 2021 by Gazi University Medical FacultyGazi Universitesi2020Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13388https://doi.org/10.12996/gmj.2021.062147-2092enGazi Medical Journalinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13388