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Antioxidant, antiepileptic, and anticholinergic properties of 4′,5,7-Trihydroxy-3,6-dimethoxyflavone as natural phenolic compound: a toxicology approachDurmaz, Lokman4′,5,7-Trihydroxy-3,6-dimethoxyflavoneacetylcholinesteraseantioxidant activityenzyme inhibitionmetabolic enzymes4',5,7 trihydroxy 3,6 dimethoxyflavoneacetazolamidealpha tocopherolanticonvulsive agentantioxidantbutylated hydroxyanisolebutylcresolcarbonate dehydratase Icarbonate dehydratase IIcholinergic receptor blocking agentcholinesterasecoppercupric ionferric ionferrous ionisoenzymenatural productphenol derivativetrolox Cunclassified drugABTS radical scavenging assayanalytic methodanticonvulsant activityantioxidant assayArticleIn this work, the antioxidant properties of 4′,5,7-trihydroxy-3,6-dimethoxyflavone using several bioanalytical assays is investigated in vitro. These methods are Cu2+-Cu+ reducing, Fe3+-Fe2+reducing, DPPH• scavenging, and ABTS•+ scavenging. The IC50 values of the 4′,5,7-trihydroxy-3,6-dimethoxyflavone for DPPH• and ABTS•+ scavenging assays were 9.36 and 3.55 μg m–1, respectively. Additionally, 4′,5,7-trihydroxy-3,6-dimethoxyflavone compound recorded best inhibitory effects against human carbonic anhydrase (hCA) I and II isoenzymes, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. 4′,5,7-Trihydroxy-3,6-dimethoxyflavone had K i value of 389.56 ± 29 nM against hCA I and 306.90 ± 41 nM toward hCA II, respectively. Also, the K i values of AChE and BChE were found as 1005.37 ± 117 nM and 814.22 ± 87 nM, respectively. © 2019 Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd.2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13391https://doi.org/10.1080/15569543.2019.16108941556-9543enToxin Reviewsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13391