2026-10-19T01:04:16Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/134142026-10-18T20:39:19Zopenairedrivercom_ebyu_10000col_ebyu_10001

Tuberculous lymphadenitis in a patient receiving pd-1 inhibitor for melanoma: A case report and brief literature reviewAkagunduz, BaranOzer, MuhammetBozkina, Ali CagatayLebe, BanuImmune checkpoint inhibitorsImmunotheraphyMelanomaNivolumabTuberculous lymphadenitisethambutolfluorodeoxyglucose f 18isoniazidmonoclonal antibodyprogrammed death 1 receptorpyrazinamiderifampicintumor markeradultapoptosisArticlebiochemical analysisblood cell countcancer screeningcase reportcell deathcell invasionclinical articlecomputer assisted tomographydisease surveillancefatiguefemalefeverfollow uphumanOncolytic immunotherapy is a novel and promising approach in clinical oncology practice. Currently, immune checkpoint inhibitors (ICIs) are the first-line treatment options for disseminated melanoma. Nivolumab is a well-defined ICI that blocks programmed cell death 1 (PD-1) and mainly increases anti-tumor immunity. The opportunistic infections are not expected with ICI therapies due to their immune reactivation effects. To date, only a few cancer patients have been reported with activated TB during ICI therapy. Here, we presented a young female patient diagnosed with histologically-confirmed tuberculous lymphadenitis while on nivolumab therapy for metastatic melanoma. The current case report represents the first described tuberculous lymphadenitis case related to anti-PD-1 based monoclonal antibody therapy. The mechanism underlying the development of TB with PD-1 inhibitor use has not been illuminated yet. Triggering of excessive inflammatory responses with ICIs therapy is a potential cause. Considering the increased utilization of ICI-based immunotherapies, the TB screening should be considered in all patients before starting PD-1 inhibitor therapy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Multimed Inc.2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13414https://doi.org/10.3390/curroncol280100281718-7729enCurrent Oncologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13414