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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/135392026-10-18T21:13:29Zopenairedrivercom_ebyu_10000col_ebyu_10001

Effect of rutin on cytarabine-associated pulmonary oedema and oxidative stress in ratsBilgin, Asli O.Mammadov, RenadSuleyman, BahadirUnver, EdhemOzcicek, FatihSoyturk, MehmetCimen, Ferda K.Kurt, NezahatSuleyman, HalisCytarabineOxidative stressPulmonary oedemaRutinAnimalsAnti-Inflammatory AgentsAntioxidantsMaleNF-kappa BOxidantsPulmonary EdemaRatsRats, WistarTumor Necrosis Factor-alphaantiinflammatory agentantioxidantimmunoglobulin enhancer binding proteinoxidizing agentrutosidetumor necrosis factoranimalblooddrug effectlung edemapathologyratWistar ratCytarabine is effectively used in the treatment of adult acute leukemia, but it has a dose-limiting side effect of fatal pulmonary oedema because it increases the vascular permeability of the alveolar capillaries. The aim of the present study was to conduct a radiological, biochemical and histopathological investigation of the effect of rutin on cytarabine-associated pulmonary oedema in rats. Rats were treated with a combination of rutin+cytarabine by administering oral rutin at a dose of 50 mg/kg; other rat groups were orally administered the same volume of physiological saline. One hour after administration of rutin or saline, the rutin+cytarabine and cytarabine groups received an intraperitoneal injection of cytarabine (200 mg/kg). This administration procedure was repeated once a day for 14 days. Radiologically, 50% of the animals given cytarabine alone showed lung oedema, but the rutin+cytarabine group showed no oedema. The inclusion of rutin decreased the amounts of cytarabine-associated malondialdehyde, tumour necrosis factor-α, and nuclear factor-κB in the lung tissue. Rutin also inhibited the reduction of total glutathione by nitric oxide. These findings suggest that rutin may be a beneficial adjunct that can minimise the development of cytarabine-associated pulmonary oedema. © 2020, Academia Brasileira de Ciencias. All rights reserved.Academia Brasileira de Ciencias2020Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13539https://doi.org/10.1590/0001-37652020201902610001-3765enAnais da Academia Brasileira de Cienciasinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13539