2026-10-18T23:16:10Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/135522026-10-18T20:28:23Zopenairedrivercom_ebyu_10000col_ebyu_10001Effect of desloratadine on oxidative and inflammatory ovarian ischemia-reperfusion injury in female rats biochemical and histopathological evaluationKadıoglu, Berrin GoktugGundogdu, BetulKurt, NezahatSuleyman, HalisSuleyman, ZeynepDesloratadineIschemiaIschemia-reperfusion injuryOvarianOvaryRatReperfusiondistilled waterglutathioneimmunoglobulin enhancer binding proteininterleukin 1betaketaminemalonaldehydetumor necrosis factoranimal experimentanimal modelanimal tissueArticlebleedingcell infiltrationcontrolled studycorpus luteumfemalehistopathologyinflammatory cellkidney tissuenonhumanovary diseaseovary tissueoxidative stressOBJECTIVE: To examine the effect of desloratadine on ovarian ischemia-reperfusion (I/R) injury in rats by biochemical and histopathological methods. STUDY DESIGN: I/R was induced in the right ovaries after distilled water was given to a group of female albino Wistar rats in this study. 15 mg/kg desloratadine was orally administered to another group and I/R was induced in their ovaries, whereas I/R was not induced in the sham operation group. After 2 hours of ischemia and 2 hours of reperfusion, malondialdehyde (MDA), total glutathione (tGSH), nuclear factor-κB (NF-κB), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) levels were measured in ovarian tissues extracted from the body of the animals sacrificed with a high dose of ketamine (120 mg/kg). Tissues were also evaluated histopathologically. RESULTS: It has been revealed that desloratadine significantly inhibited the increase of I/R-associated MDA, NF-κB, IL-1β, and TNF-α levels in the ovarian tissues of animals and the decrease in tGSH levels. In addition, desloratadine decreased severe I/R-associated histopathological damage. CONCLUSION: Our experimental results have shown that desloratadine is beneficial in terms of protecting ovarian tissue against I/R injury. © Science Printers and Publishers, Inc.Science Printers and Publishers Inc.2020Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/135522578-742XenAnalytical and Quantitative Cytopathology and Histopathologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13552