2026-10-19T01:08:44Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/135552026-10-18T20:43:17Zopenairedrivercom_ebyu_10000col_ebyu_10001The negative effect of desflurane on reproductive capacity in female ratsTurkler, C.Kulhan, M.NG, KulhanOnat, T.Yildirim, E.Kaplan, S.Suleyman, H.Dinc, K.DesfluraneInfertilityOxidative stressRatReproductive capacityAnimalsAntioxidantsFemaleGlutathione PeroxidaseInfertility, FemaleMalondialdehydeRatsRats, WistarSuperoxide Dismutaseantioxidantmalonaldehydeanimaldrug effectfemale infertilityWistar ratAIM: The aim of this study was to determine the effect of desflurane on reproductive capacity in female rats through a study of biochemical evaluations. METHOD: After experimental procedure, the blood samples of female rats were collected, and the malondialdehyde, interleukin-1-beta, total glutathione and superoxide dismutase levels were measured to evaluate oxidative stress. In addition to biochemical evaluations, the reproductive performance of the experimental groups was also examined. RESULTS: The results of our study demonstrated that in blood samples of desflurane-treated groups of rats, the parameters indicating oxidative stress and inflammation increased, and antioxidant parameters decreased (p < 0.05). It was also proven that repeated desflurane doses caused infertility in female rats, prolonged the gestation period and reduced the number of offspring. CONCLUSIONS: This study showed that recurrent desflurane application can cause infertility problems through oxidative stress in female rats (Tab. 3, Fig. 1, Ref. 25). Text in PDF www.elis.sk. © 2020, Comenius University.Comenius University2020Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13555https://doi.org/10.4149/bll_2020_0090006-9248enBratislava Medical Journalinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13555