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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/136242026-10-18T20:28:27Zopenairedrivercom_ebyu_10000col_ebyu_10001

The role of torque teno virus (Ttv) viremia in sarcoidosis etiologyTeke, TurgutFeyzioglu, BahadirTosun, MustafaDogan, MetinYesildag, KerimOzdemir, MehmetEtiologyInfectionSarcoidosisTorque teno virusadultArticlecancer stagingclinical articlecontrolled studyDNA determinationDNA purificationfemalehistologyhumanhuman tissuehybridizationmalemiddle agedprevalenceprospective studyreal time polymerase chain reactionthorax radiographyTorque teno virus 1Torque teno virus infectionvirus loadObjective: To investigate a possible role of torque teno virus (TTV) in the etiology of sarcoidosis Design: Controlled prospective study Setting: Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey Subjects: This cross-sectional, clinical study included 37 sarcoidosis patients and 9 healthy control patients. Intervention: TTV DNA quantification was performed by real-time PCR by the hybridization probe system, and viral load was interpreted by means of the crossing point (CP) value in sera of subjects. Main outcome measures: The prevalence and viral load of TTV Results: TTV DNA was detected in the majority of both patients and healthy controls. The prevalence was 59.5% in patients and 55.6% in controls. This difference was not statistically significant. However, CP values were statistically different in the patient group from the control group (p <0.001); namely, the viral load of TTV was higher in the patient group than in the healthy control group. Conclusions: Overall, these findings demonstrate for the first time that TTV plays a role in the etiology of sarcoidosis. It is likely that the role of TTV in the pathogenesis of sarcoidosis is an aberrant immune response, driven by viral antigens. © 2019, Kuwait Medical Association. All rights reserved.Kuwait Medical Association2019Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/136240023-5776enKuwait Medical Journalinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13624