2026-10-19T01:05:09Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/138302026-10-18T21:14:20Zopenairedrivercom_ebyu_10000col_ebyu_10001

Thiol-Disulfide Homeostasis, Serum Ferroxidase Activity, and Serum Ischemia Modified Albumin Levels in Childhood Iron Deficiency AnemiaTopal, IsmailMertoglu, CumaSürücü Kara, IlknurGok, GamzeErel, Ozcanferroxidase activityiron deficiency anemiaischemia-modified albuminthiol-disulfide homeostasisAdolescentAnemia, Iron-DeficiencyBiomarkersCase-Control StudiesCeruloplasminChildChild, PreschoolDisulfidesFemaleHomeostasisHumansInfantMaleOxidative StressSerum AlbuminSerum Albumin, HumanSulfhydryl Compoundsdisulfideferritinhemoglobinironischemia modified albuminthiolbiological markerhuman serum albuminthiol derivativeAim: The aim is to compare the markers of oxidative stress in iron deficient children to that of non-anemic children. Method: Serum thiol-disulfide level, ferroxidase activity and ischemia-modified albumin (IMA) levels were compared between iron deficiency anemia (IDA) and non-anemic children. Results: A total of 117 children, 66 with IDA and 51 non-anemic children were included in the study. Disulfide, disulfide/native thiol, and disulfide/total thiol levels were significantly higher in the IDA group (p: 0.001). Serum ferroxidase levels were significantly lower in the IDA group (p: 0.04); but there was no significant difference between the two groups regarding serum IMA levels (p: 0.42). There was a weak negative correlation between disulfide and serum hemoglobin (p: 0.004), iron (p: 0.041), and ferritin (p: 0.023) levels while there was a weak positive correlation between ferroxidase activity and these parameters. Conclusion: There is an increased protein oxidation in children with IDA compared with non-anemic controls. © 2019, © 2019 Taylor & Francis Group, LLC.Taylor and Francis Ltd2019Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13830https://doi.org/10.1080/15513815.2019.16276261551-3815enFetal and Pediatric Pathologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13830