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Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff basesDurgun, MustafaTürkeş, CüneytIşık, MesutDemir, YelizSaklı, AliKuru, AliGüzel, AbdussamatBeydemir, ŞükrüAkocak, SuleymanOsman, Sameh M.AlOthman, ZeidSupuran, Claudiu T.Acetylcholinesterasecarbonic anhydrasemolecular dockingsulphonamidesynthesisAntioxidantsBenzothiazolesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCholinesterase InhibitorsDose-Response Relationship, DrugHumansMolecular StructureSchiff BasesStructure-Activity RelationshipSulfonamidesSulfonic Acids3 [(3 bromo 2 hydroxybenzyl)amino]benzenesulfonamide3 [(3 bromo 2 hydroxybenzylidene)amino]benzenesulfonamide3 [(3 chloro 2 hydroxybenzyl)amino]benzenesulfonamide3 [(3 chloro 2 hydroxybenzylidene)amino]benzenesulfonamide4 [(3 bromo 2 hydroxybenzyl)amino]benzenesulfonamide4 [(3 bromo 2 hydroxybenzylidene)amino]benzenesulfonamide4 [(3 chloro 2 hydroxybenzyl)amino]benzenesulfonamide4 [(3 chloro 2 hydroxybenzylidene)amino]benzenesulfonamideacetazolamideamineantioxidantcarbonate dehydratase Icarbonate dehydratase IISulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, 13C NMR, 1H NMR, LC-MS and elemental analysis. Their inhibitory effect on AChE, and carbonic anhydrase I and II enzyme activities was investigated. Their antioxidant activity was determined using different bioanalytical assays such as radical scavenging tests with ABTS•+, and DPPH•+ as well as metal-reducing abilities with CUPRAC, and FRAP assays. All compounds showed satisfactory enzyme inhibitory potency in nanomolar concentrations against AChE and CA isoforms with KI values ranging from 10.14 ± 0.03 to 100.58 ± 1.90 nM. Amine group containing derivatives showed high metal reduction activity and about 70% ABTS radical scavenging activity. Due to their antioxidant activity and AChE inhibition, these novel compounds may be considered as leads for investigations in neurodegenerative diseases. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd2020Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13901https://doi.org/10.1080/14756366.2020.17467841475-6366enJournal of Enzyme Inhibition and Medicinal Chemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13901