2026-10-19T01:12:04Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/139312026-10-18T21:13:29Zopenairedrivercom_ebyu_10000col_ebyu_10001The effect of Liv-52 on liver ischemia reperfusion damage in ratsCimen, OrhanEken, HüseyinKeskin Cimen, FerdaCekic, Arif BurakKurt, NezahatOzbek Bilgin, AsliSuleyman, BahadirSuleyman, HalisMammadov, RenadPehlivanoglu, KamilKurnaz, ErayInjuryIschemia reperfusionLiv-52LiverRatAlanine TransaminaseAnimalsAntioxidantsAspartate AminotransferasesDrug CombinationsGlutathioneGlutathione PeroxidaseGlutathione ReductaseGlutathione TransferaseL-Lactate DehydrogenaseMaleMalondialdehydePeroxidasePlant ExtractsRats, WistarReperfusion InjurySuperoxide Dismutasealanine aminotransferaseaspartate aminotransferaselactate dehydrogenaseliv 52malonaldehydemyeloperoxidaseantioxidantplant extractBackground: Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats. Methods: Albino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals. Results: Increased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically. Conclusions: Liv-52 may be beneficial for preventing liver I/R damage in pre-surgery application. © 2020 The Author(s).BioMed Central2020Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/13931https://doi.org/10.1186/s40360-019-0380-02050-6511enBMC Pharmacology and Toxicologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/13931