2026-10-19T01:56:37Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/140022026-10-18T21:13:28Zopenairedrivercom_ebyu_10000col_ebyu_10001The effect of rutin on experimental traumatic brain injury and edema in ratsYuceli, SahinYazici, Gulce NazMammadov, RenadSuleyman, HalisKaya, MustafaOzdogan, SelcukBrain edemaRutinTraumatic brain injuryAnimalsBrainBrain Injuries, TraumaticEdemaMalondialdehydeRatsglutathioneimmunoglobulin enhancer binding proteinmalonaldehyderutosidetumor necrosis factoranimal cellanimal experimentanimal modelanimal tissueantiinflammatory activityArticleastrocytebrain homogenatebrain tissuecontrolled studyexperimental traumatic brain injuryglia cellhistopathologyleukocytemalenerve cell degenerationBackground/Aim: The aim of the study was to evaluate the effect of rutin, which is a vitamin P1 flavonoid with anti-inflammatory and anti-edema effects, on traumatic brain injury (TBI) and edema in rats. Materials and Methods: Rats were divided into 3 groups as sham group without brain trauma (SG), brain trauma without medication (BT) group and Rutin treated brain trauma (RBT) group. Fifty mg/kg rutin was administered to the RBT group once a day for three days. On the fourth day, rats were sacrificed. Extracted brain tissues were examined biochemically and histopathologically. Results: We found that the levels of malondialdehyde, nuclear factorkappa B and tumor necrosis factor-alpha decreased, and those of total glutathione increased significantly. Furthermore, rutin administration reduced pyramidal neuron degeneration and poly-morpho-nuclear-leucocyte accumulation due to trauma in brain tissue, while eliminating edema. Conclusion: Rutin might be effective in the treatment of TBI and TBI-related brain edema. © 2020 International Institute of Anticancer Research. All rights reserved.International Institute of Anticancer Research2020Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14002https://doi.org/10.21873/invivo.120600258-851XenIn Vivoinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14002