2026-10-19T03:29:50Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/140322026-10-18T21:14:21Zopenairedrivercom_ebyu_10000col_ebyu_10001

Antimicrobial activities of new indole derivatives containing 1,2,4-triazole, 1,3,4-thiadiazole and carbothioamide; [1,2,4-triazol, 1,3,4-tiyadiazol ve karbotiyoamit içeren yeni indol türevlerinin antimikrobiyal aktiviteleri]Shirinzadeh, HanifSüzen, SibelAltanlar, NurtenWestwell, Andrew D.1,2,4-triazole1,3,4-thiadiazoleC. kruseiIndoleMRSA1,2,4 triazole derivative1,3,4 thiadiazole derivativeampicillincarbothioamideciprofloxacinfluconazoleindole derivativesultamicillinunclassified drugantibacterial activityantifungal activityantimicrobial activityArticleBacillus subtilisbacterium cultureCandida albicansdrug analysisdrug efficacydrug synthesisEscherichia colimethicillin resistant Staphylococcus aureusminimum inhibitory concentrationnonhumanPichia kudriavzeviiStaphylococcus aureusObjectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy. Materials and Methods: The efficacy of new compounds was evaluated using 2-fold serial dilutions against Staphylococcus aureus, MRSA, Escherichia coli, Bacillus subtilis, Candida albicans, and Candida krusei. Results: The MIC was determined for test compounds and for the reference standards sultamicillin, ampicillin, fluconazole, and ciprofloxacin. Conclusion: The compounds possessed a broad spectrum of activity having MIC values of 3.125-50 µg/mL against the tested microorganisms. This study provides valuable evidence that the indole-triazole derivative compound 3d holds significant promise as a novel antibacterial and antifungal lead compound. © Turk J Pharm Sci, Published by Galenos Publishing House.Turkish Pharmacists Association2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14032https://doi.org/10.4274/tjps.557071304-530XenTurkish Journal of Pharmaceutical Sciencesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14032