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Myo-inositol oxygenase as a novel marker in the diagnosis of acute kidney injuryMertoglu, CumaGunay, MuratGurel, AliGungor, MehmetAcute kidney injuryMyo-inositol oxygenaseNeutrophil gelatinase-Associated lipocalin and cystatin ccreatininecystatin Cinositol oxygenaseneutrophil gelatinase associated lipocalinnitrogenureaacute kidney failurearea under the curveArticleclinical articlecontrolled studycreatinine blood leveldiagnostic accuracydiagnostic test accuracy studyenzyme linked immunosorbent assayfemalehumanmalesensitivity and specificityurea nitrogen blood levelBackground: Due to the lack of diagnostic efficiency of serum creatinine in acute kidney injury (AKI), there is a pressing need to develop novel diagnostic markers. Therefore, in this study, we evaluated myo-inositol oxygenase (MIOX), neutrophil gelatinase-Associated lipocalin (NGAL) and cystatin C in terms of their applicability in the diagnosis of AKI. Methods: We enrolled a total of 39 AKI patients and 38 healthy controls in the study. We compared the levels of serum MIOX, NGAL and cystatin C between the two groups. Results: We found that the concentrations of serum creatinine, blood-urea nitrogen, MIOX and cystatin C were higher in the AKI group. According to the receiver operating characteristic analysis, the area under the curve (AUC) values were 0.694 (95% CI 0.579-0.794) for MIOX and 0.976 (95% CI; 0.912-0.997) for cystatin C. For MIOX, when the cut-off concentration was set to 77.3 pg/mL, the diagnostic sensitivity and specificity were found to be 53.8% (95% CI; 37.2-69.9) and 81.5 (95% CI; 65.7-92.3), respectively. For cystatin C, at the cut-off value of 14 mg/L, the diagnostic sensitivity and specificity were 94.8% (95% CI; 82.7-99.4) and 94.7 % (95% CI 82.3-99.4), respectively. Conclusions: The measurement of serum MIOX and cystatin C levels is valuable for the diagnosis of AKI. Further research is needed for the evaluation of the potential use of MIOX as a kidney-specific enzyme in the early diagnosis of AKI.Society of Medical Biochemists of Serbia and Montenegro2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14056https://doi.org/10.1515/jomb-2017-00271452-8258enJournal of Medical Biochemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14056