2026-10-18T23:53:53Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/140632026-10-18T20:28:51Zopenairedrivercom_ebyu_10000col_ebyu_10001The effect of parecoxib on testicular ischemia/reperfusion injury in ratsBayrak, OguzhanCimen, Ferda K.Hirik, ErkanGulaboglu, MineSuleyman, ZeynepSuleyman, BahadirParecoxibRatTestisTorsioncyclooxygenase 1cyclooxygenase 2glutathioneinterleukin 1betamalonaldehydetumor necrosis factoranimal experimentanimal modelanimal tissueantiinflammatory activityantioxidant activityArticlebiochemical analysiscontrolled studydrug dose comparisondrug efficacyenzyme activityenzyme linked immunosorbent assayfollow uphistopathologyischemiamalenonhumanoxidative stressreperfusion injurytesticular ischemiaThe aim of this study was to investigate the effects of parecoxib on the ischemia/reperfusion (I/R) injury induced in rats by torsion-detorsion. Parecoxib was injected to all the rats intraperitoneally once prior to the torsion-detorsion. The ischemia/reperfusion and sham surgery groups were given the same volume of distilled water. One h later, torsion and detorsion were performed, each for two h, on the ischemia/reperfusion + 10 mg/kg parecoxib, ischemia/reperfusion + 20 mg/kg parecoxib, and ischemia/reperfusion groups. The results of the biochemical test showed that 20 mg/kg dose of parecoxib was more effective than the 10 mg/kg dose in inhibiting the increase in the MDA, COX-2, IL-1β and TNF-α levels and decrease in tGSH and COX-1 in the testicular tissue treated with torsion-detorsion. Furthermore, it was also histopathologically shown that the 20 mg/kg dose better prevented torsion-detorsion injury. The experimental results suggest that parecoxib will be clinically useful in the treatment of testicular I/R injury due to torsion-detorsion. © 2018, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.Colegio de Farmaceuticos de la Provincia de Buenos Aires2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/140630326-2383enLatin American Journal of Pharmacyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14063