2026-10-18T23:56:51Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/140782026-10-18T21:14:22Zopenairedrivercom_ebyu_10000col_ebyu_10001

Evaluation of the effect of retrograde intrarenal surgery with myo-inositol oxygenaseMertoglu, CumaBozkurt, AliseydiKeskin, ErcümentGunay, MuratAcute kidney injuryCreatinineCystatin CMyo-inositol oxygenaseRetrograde intra-renal surgeryinositol oxygenaseacute kidney failureadultArticlebiochemical analysisblood samplingclinical articleclinical effectivenesscontrolled studycorrelation coefficientcreatinine blood levelenzyme blood levelfemalehumankidney functionkidney surgerymalenephrolithiasispatient safetyprospective studyretrograde intrarenal surgeryObjective: To investigate the effect of retrograde intra-renal surgery (RIRS) on kidneys using the myo-inositol oxygenase (MIOX) enzyme. MIOX is a renal tubular-specific novel marker for the early diagnosis of acute kidney injury. Methods: A total of twenty seven individuals that had undergone RIRS to treat kidney stones were included in the study. Biochemical tests were performed on serum samples collected immediately before RIRS (hour 0) and at the 6th and 24th hours after the surgery. Results: The creatinine value at hour 6 was lower than the baseline (hour 0) value (p = 0.0305). Cystatin C at hour 6 was lower than the value measured at hour 24 (p = 0.0142). Similarly, MIOX was lower at hour 6 compared to hour 24 (p = 0.0214). MIOX/creatinine at hour 6 was lower than the value calculated at hour 24 (p = 0.0348). The basal values of MIOX and creatinine were found to have a positive correlation (correlation coefficient r = 0.5946, p = 0.0035). Conclusions: Similar to the serum creatinine, the serum MIOX level provides information about kidney functions. RIRS was confirmed to be a safe procedure for the treatment of acute kidney injury with no negative effects on the kidneys. © 2018, Professional Medical Publications. All rights reserved.Professional Medical Publications2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14078https://doi.org/10.12669/pjms.341.140941682-024XenPakistan Journal of Medical Sciencesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14078