2026-10-18T23:56:49Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/142002026-10-18T21:13:30Zopenairedrivercom_ebyu_10000col_ebyu_10001Immunostaining characteristics of irisin in benign and malignant renal cancersKuloğlu, T.Artaş, G.Yardim, M.Sahin, I.Aydin, Y.Beyoğlu, N.Özercan, İ. H.Yalcin, M.H.Ugur, K.Aydin, S.Cancerchromophobe RCCclear cell RCCFuhrman nuclear gradeirisinoncocytomarenal tissueAdenoma, OxyphilicAlgorithmsBiomarkers, TumorCarcinoma, Renal CellDiagnosis, DifferentialHumansImmunohistochemistryKidney NeoplasmsTranscription Factorstranscription factortumor markeralgorithmdifferential diagnosishumankidney tumormetabolismpathologyproceduresrenal cell carcinomaWe investigated the expression of irisin in renal cancers using immunocytochemistry. Irisin has been reported to exhibit anticancer properties. The study groups consisted of 22 cases each of control renal tissue, oncocytoma, chromophobe renal cell carcinoma (RCC), clear cell RCC (Fuhrman nuclear grades 1, 2, 3 and 4) and papillary RCC. We evaluated 10 slides for each of 176 cases. Slides were immunostained for irisin and histoscores were calculated for the prevalence and strength of immunostaining. Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC exhibited no irisin immunoreactivity. Irisin immunoreactivity was observed in some Fuhrman nuclear grade 4 RCCs. We found a significant decrease in irisin staining in chromophobe RCC compared to the control. Immunoreactivity in the oncocytoma tissue was comparable to the control group. Irisin immunoreactivity in chromophobe RCC decreased and no immunoreactivity was observed in Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC. Immunistochemical screening of irisin in renal oncocytomas and renal cancers may be useful for differential diagnosis. © 2019, © 2019 The Biological Stain Commission.Taylor and Francis Ltd2019Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14200https://doi.org/10.1080/10520295.2019.15869981052-0295enBiotechnic and Histochemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14200