2026-10-19T00:01:57Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/142472026-10-18T21:13:30Zopenairedrivercom_ebyu_10000col_ebyu_10001Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in ratsEken, HüseyinCimen, OrhanCimen, Ferda KeskinKurnaz, ErayYildirim, MuratTasova, VolkanKurt, NezahatPehlivanoglu, KamilOnk, DidemBilgin, Asli OzbekCeliac ArteryIschemiaRatsReperfusionTaxifolinAnimalsAnti-Inflammatory Agents, Non-SteroidalDisease Models, AnimalGastric MucosaLigationMaleOxidation-ReductionOxidative StressQuercetinRats, WistarReperfusion Injuryglutathioneglutathione peroxidasehydrogen peroxidemalonaldehydesuperoxide dismutasenonsteroid antiinflammatory agentanimal experimentanimal modelanimal tissueantioxidant activityartery ligationArticlecell destructioncell infiltrationPurpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure. © 2019, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia2019Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14247https://doi.org/10.1590/s0102-8650201900400000040102-8650enActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14247